Ceftriaxone Sodium Injection Powder

Warning

It is strictly prohibited for food and feed processing this product cannot be added to solutions containing calcium such as hartman's and ringer's.

The combination of this product with calcium-containing agents or calcium-containing products may lead to adverse events that may lead to fatal outcomes.

Ingredient

Ceftriaxone Sodium Injection Powder chemical name: (6r, 7r)-7-(2-amino-4-pyridine) (methoxysamine) acetyl-amino-8-oxygen-3-(1,2,5,6-tet hydrogen-2-a) base-5, 6-dioxygen-1,2,4-triglyceride-3-base-sulfur-methyl-5-sulfur-1-nitrogen double ring (4.2.0) xin-2-ene-2-disodium nitrite three times the semi-hydrate.

Chemical structure:

Molecular: C₁₈H₁₆N₈Na₂O₇S₃· 3½ H₂O

Molecular Weight: 661.59

Molecular Weight: 661.59

Characters

This product is white or white crystalline powder.

Indications

Used for the prevention of lower respiratory tract infections, urinary tract and bile duct infections caused by sensitive pathogenic bacteria, as well as abdominal infections, pelvic infections, skin soft tissue infections, bone and joint infections, sepsis, meningitis, etc. And surgical-period infections. This single dose can treat simple gonorrhea.

Specification

Press C₁₈H₁₈N₈O₇S₃1.0g

Usage Usage

Intramuscular injections or intravenous drip administration.

(1) preparation of intramuscular injection solution: 3.6 ml sterilization injection water, sodium chloride injection, 5% glucose injection or 1% hydrochloric acid lidokain added to 1g bottle, to make a solution containing 250 mg cephalosporine per 1 ml.

(2) preparation of intravenous administration solution: 9.6 ml of the aforementioned dilution (except lidokain) into 1g bottle, to make every 1 ml containing 100 mg cephalosporine solution, and then with 5% glucose injection or sodium chloride injection 100 to 250 ml diluted intravenous drip.

Adults commonly used amount of intramuscular or intravenous drip, every 24 hours 1 to 2g or every 12 hours 0.5 to 1g. The highest dose is 4g a day. Treatment from 7 to 14 days.

Children often use a quantity of intravenous drip, according to the weight of 20 to 80 mg /kg a day. Adult doses for children over 12 years of age.

The recommended dose for the treatment of gonorrhea is 0.25g for intramuscular injection.

Adverse Reactions

Adverse reactions are related to the dose and course of treatment. Local reactions include intravenous inflammation (1.86%), in addition to allergic reactions such as rash, dermatitis, itching, urticaria, edema, fever, bronchial spasms and serological disease (2.77%), headache or dizziness (0.27%), digestive tract reactions such as stooling, diarrhea, nausea, vomiting, bronchitis, abdominal pain, colitis, jaundice, bloating, taste disorders and indigestion (3.45%). Laboratory examination abnormalities of about 19%, of which hematologic examination abnormalities accounted for 14%, including increased eosinophils, bleeding, platelets increased or decreased and white blood cells decreased. Liver and kidney dysfunction was 5% and 1.4%. Other rare side effects include increased liver enzymes and less urine.

Taboo

Banned for people allergic to cephalosporin antibiotics.

Precautions

1. Allergy tests are required before administration.

2. Cross-allergic reaction: people who are allergic to one type of cephalosporin or cephalomycin may also be allergic to other cephalosporins or cephalomycin. People who are allergic to penicillin, penicillin derivatives, or penicillin may also be allergic to cephalosporins or cephalomycin. Allergic reactions to cephalosporins in patients with penicillin allergy ranged from 5% to 10%, and 20% in patients with penicillin allergy when immunologically tested.

3. When applying this product to penicillin allergy patients, it should be decided after the patient's condition has fully weighed the pros and cons. If there is penicillin allergic shock or immediate reaction, it is not appropriate to choose cephalosporins.

4. People with a history of gastrointestinal diseases, especially ulcerative colitis, limited enteritis or antibiotic-related colitis (cephalosporins rarely produce pseudo-membrane colitis) should be used with caution.

5. Due to the low toxicity of cephalosporins, patients with chronic liver disease do not need to adjust the dose when applying this product. Patients with severe liver and kidney damage or cirrhosis should adjust the dose.

6. The removal of creatinine in patients with renal insanity is greater than 5 ml/min, and no dose adjustment is required when the daily dose of this product is less than 2g. Hemodialysis removal of the amount of this product is not much, dialysis after the need to add dose.

7. Interference with diagnosis: patients who use this product can obtain false positive reaction when using copper sulfate to measure urinary sugar, and the law of glucose is not affected;

8. When this product is injected with deep hip muscle, each side shall not exceed 1g.

9. Freshly formulated solution can be kept under 5 degrees c for 24 hours, while only 6 hours can be stored at room temperature.

10. This product and amino saccharide drugs can not be mixed in the same syringe injection, must be injected separately.

11. This product cannot be added to solutions containing calcium such as hartman's and ringer's.

12. Discarded drug packaging should not be discarded at will.

Medication for Pregnant and Lactating Women

The application of cephalosporins in pregnant and lactating women has not yet been reported as a problem, and its application still has to weigh the pros and cons.

Children's Medicine

The safety of medication for newborns (those born weighing less than 2 kg) has not yet been determined. Newborns with jaundice or with severe jaundice tendencies should use this product with caution or avoid it.

Medication for the Elderly

Unless the elderly patient is weak, malnourished or has severe renal impairment, the elderly do not generally need to adjust the dose of cephalosporine.

Drug Interactions

1. Cephalosporin intravenous fluids added to erythromycin, tetracycline, amycin b, angioactive drugs (interseroamine, norepinephrine, etc.), Benzoin sodium, chloropropyl, isopropyl, vitamin b, vitamin c, etc. Will appear cloudy. Because there are many contraindication drugs in this product, they should be administered separately.

2. When drinking alcohol or taking alcoholic drugs during the application of this product, double thiopental-like reactions may occur in individual patients, so alcohol consumption and alcohol-containing drugs should be avoided during the application of this product and for several days thereafter.

Drug Overdose

It is not clear.

Pharmacological Toxicology

This product is a third generation of cephalosporin antibiotics. Strong activity for e. Coli bacteria. Mic for e. Coli, pneumococcal creber, e. Coli, fluorotrecillate, pyrethroids, pruitt and sarepta90between 0.12 and 0.25mg/l. The sensitivity of coliform e. Coli, campylobacter genus and copper-green pseudomonas to this product is poor. It has strong antibacterial effects on haemophilus influenzae, gonorrhea neisseria and meningitis neisseria, and also has good effect on hemolytic streptococcus and pneumococcal bacteria. The mic for staphylococcus aureus is 2 to 4 mg/l. Methicillin-resistant staphylococcus and enterococci resistant to this product. Most fragile mycobacterium is resistant to this product.

Pharmacokinary Dynamics

Intramuscular injection of 0.5g and 1g, about 2 hours after reaching the peak concentration of blood medicine (cmax), 43mg/l and 80mg/l, respectively. The blood concentration for 24 hours after intramuscular injection was 6.0 mg/l, and the blood elimination half-life (t1/2β7.1 hours. Within 1 minute, a 0.5g injection is made, and the blood concentration (c) is immediately reduced to the peak of the blood medicinemaxfor 150.9mg/l, after 24 hours the concentration of blood drugs is 9.9mg/l, blood elimination half-life (t1/2b7.87 hours. Within 30 minutes, drop the product lg, the immediate peak concentration of the blood medicine at the end of the drip (cmaxthe blood concentration was 9.3mg/l for 24 hours at 150.7mg/l. After 15 to 20 mg/kg of intramuscular injections per day, the concentration of cerebrospinal fluid for 6 hours was 5.16 mg/l on average and 2.3 mg/l for 12 hours. The concentrations in bile were 1600 mg/l and 13.5 mg/l, respectively, 5 hours after intravenous drips of this product. The protein binding rate is 95%. Cephalosporine is not metabolized in the body, and about 40% of the drugs are excreted from the bile ducts and intestines in their original form and 60% from the urine. Propulsion should not increase the concentration of this blood drug or extend its half-life.

Storage

Shade, closed, stored in a cool, dry place (no more than 20 degrees c).

Wrap

Packaging materials: injection bottles and medicinal halogenated butyl rubber plugs

Packaging specifications: 10 bottles per box or 1 bottle per box (with 10 ml of sterilized injection water) or 1 bottle per small box.

Expiration Date

30 months.

Enforce the Standard

The 2010 edition of the chinese pharmacopoeia.

E-mail: lilyoo@bbcapharma.com