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Amoxicillin Capsules

Amoxicillin, also known as amoxicillin or amoxicillin, is one of the most commonly used semi-synthetic penicillin-class broad-spectrum β -lactam antibiotics.
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    BBCA PHARMA
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    5000000
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  • Product Origin:

    China
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    White
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Product Detail
E-mail: lilyoo@bbcapharma.com

Amoxicillin, also known as amoxicillin or amesililin, is one of the most commonly used semi-synthetic penicillin-like broad-spectrum β-endamide antibiotics, a white powder with a half-life of about 61.3 minutes. Stable under acidic conditions, gastrointestinal absorption rate of 90%. Amocillin has a strong bactericidal effect and a strong ability to penetrate cell membranes. Is currently widely used oral semi-synthetic penicillin one, its preparations have capsules, tablets, granules, dispersion tablets and so on, and now often used with kravic acid to make dispersive tablets.

Introduction to Compounds

Basic Information

Chinese name: amasilin

Chinese aliases: amofeng, amorim, amosian, amoxin, amusilin, anfushin, onahin, flemosa star, phentasilin, guanglin, naitan, qiang bilin, strong amosian, trice, shindabenen, isalin, oxyassilin, relin, reling amosian, vic amosi

English name: amoxicillin

English aliases: almodan, amolin, bristamox, amoxa, amoxicilline, amoxicillingum, amoxicllin, amoxil, amoxipen, amoxycillin, brl-2333, bristamox, capsules, clamoxil, clamoxyl, daxipen, flemoxin, larocin、natamox、oxetacillin

Chemical names: (2s, 5r, 6r)-3, 3-dimethyl-6-(r)-(-)-2-amino-2-(4-hydroxybenzene) acetylamide)-7-oxygen generation-4-sulfur-1-nitrogen-hybrid double-ring(3.2.0) pyrene-2-methyl acid trihydrate.

Pinyin name: amoxilin

Cas: 26787-78-0

Molecular: c16h19n3o5s·3h2o

Molecular weight: 419.46

Materialized Nature

Appearance and character: solid

Density: 1.54g/cm3

Boiling point: 743.2oc at 760 mmhg

Flash point: 403.3oc

Stability: stable and incompatible with strong oxidants

Storage conditions: 2-8oc

Steam pressure: 3.39e-23mmhg at 25c

Security Information

Customs code: 2941109200

Danger category code: r42/43

Safety note: s22-s36/37

Dangerous goods logo: xn

Use

Antibiotics. Amosilin has a strong bactericidal effect and a strong ability to penetrate cell walls. Is currently widely used oral penicillin one of the preparations have capsules, tablets, granules, dispersion tablets and so on. Penicillin allergy and penicillin skin test positive patients are disabled.

E-mail: lilyoo@bbcapharma.com

Pharmacopeia Standards

Source (name), Content (value)

This product is (2s, 5r, 6r)-3, 3-dimethyl-6-(r)-(-)-2-amino-2-(4-hydroxybenzene) acetylamine-7-oxygen generation-4-sulfur hybrid-1-nitrogen-hybrid double-ring(3.2.0) argon-2-methyl acid trihydrate. Based on the absence of water, c16h19n3o5s shall not be less than 95.0%.

Characters

This product is white or white crystalline powder; this product is slightly soluble in water and almost insoluble in ethanol.

Than the spin take this product, precision weighing, water dissolved and quantitatively diluted into each 1 ml containing about 2 mg of solution, according to the law (2010 edition of the pharmacopeia ii appendix vi.E), the ratio of rotation of 290 degrees to 315 degrees.

Differential

(1) Take this product and amosilin control products about 0.125g each, respectively, plus 4.6% sodium bicarbonate solution dissolved and diluted into each 1 ml containing about 10 mg of amosylin solution, as a test solution and control solution The Amoxilin control and cephalosporine control were taken in the appropriate amount, plus 4.6% sodium bicarbonate solution dissolved and diluted into a solution containing about 10 mg of amosylin and 5 mg of cephalosporin per 1 ml as a systematic applicability test solution. The thin layer chromatography method (2010 edition of the Pharmacopeia II Appendix V.B) test, drawing on each of the above three solutions 2 sl, pointing at the same silicone GF254 thin layer plate, with acetate-acetone-ice acetic acid-water (5:2:2:1) as an expander, expanded, dried, 254nm ultraviolet light under the inspection. The system suitability test solution should show two clearly separated spots, and the position and color of the main spots shown in the test solution should be the same as the position and color of the main spots of the control solution.

(2) In the chromatography recorded under content determination, the retention time of the main peak of the solution for the test should be consistent with the retention time of the main peak of the control solution.

(3) The infrared light absorption map of this product shall be consistent with the control map (drug infrared spectroscopy collection 441).

the above (1), (2) two optional to do one.

Examine

Acidity

Take this product, add water to make a solution containing 2 mg per 1 ml, according to the law (2010 edition of the pharmacopoeia ii appendix vi. H), ph should be 3.5 to 5.5.

The degree of clarity of the solution

Take 5 parts of this product, each 1.0g, respectively, plus 0.5mol/l hydrochloric acid solution 10 ml, immediately after dissolution observation, and take 5 copies of this product, each 1.0g, respectively, plus 2mol/l ammonia solution 10 ml dissolved immediately after observation, the solution should be clarified. If it appears cloudy, it should not be more intense than the turbidity standard liquid no. 2 (appendix ix .B of the 2010 edition of the pharmacopeia ii).

Related substances

Take the appropriate amount of this product, precision weighing, plus liquid phase a dissolved and quantitative dilution into each 1 ml containing about 2.0 mg of solution, as a test solution, and take the appropriate amount of amosilin control, precision weighing, with flow phase a dissolved and quantitatively diluted into a solution containing about 20 μg per 1 ml, as a control solution. The high-efficiency liquid chromatography method (appendix v. D. Ii of the 2010 edition of the pharmacopeia) was determined to be filled with 18 alkyl silane bonding silicone, and 0.05mol/l phosphate buffer (with 0.05mol/l phosphate dihydro potassium solution, with 2mol/l hydrogen) potassium oxide solution regulates ph to 5.0) - acetylene (99:1) is the flow phase a, 0.05mol/l phosphate buffer (ph 5.0) - acetylene (80:20) is the flow phase b, and the detection wavelength is 254nm. First to the flow phase a-flow phase b (92;8) iso-elution, until the amosilin peak elution is completed immediately after the table linear gradient elution. Take the amoxilin system applicability control products in the appropriate amount, plus the flow phase a dissolved and diluted into each 1 ml containing about 2.0 mg of solution, take 20 μl injection liquid chromatography, the recorded chromatographic map should be consistent with the standard map. The control solution is injected with a liquid chromatograph to adjust the detection sensitivity, so that the peak height of the main component chromatography peak is about 25% of the full scale. Then precision quantity of the test solution and control solution each 20 μl, respectively injected into the liquid chromatography, record chromatography, for the test solution chromatography map, such as impurity peak, a single impurity peak area shall not be greater than the main peak area of the control solution (1 .0%), the sum of the impurity peak area shall not be greater than 3 times the main peak area of the control solution (3.0%), and any peak less than 0.05 times the main peak area of the control solution in the chromatography of the test solution shall be negligible.

Measured by molecular exclusion chromatography (appendix v. H, 2010 edition ii of the pharmacopoeia).

1 chromatographic conditions and system suitability test

With glucose gel g-10 (40 to 120 m) as a filler, glass column diameter 1.0 to 1.4cm, column length 30 to 40cm, flow phase a is ph 8.0 0 0.0 0.0.0 0.0mol/l phosphorus the acid buffer (0.05mol/l phosphate hydrododium solution -0.05mol/l phosphate dihydrogen solution (95:5)) has a flow phase b of water at a flow rate of 1.5 ml per minute and a detection wavelength of 254nm. Take 0.2mg/ml blue glucose 2000 solution 100 to 200 μl injection liquid chromatograph, respectively, to the flow phase a, b for the flow phase determination, record chromatographic map. According to the blue glucan 2000 peak calculation the theoretical plate number is not less than 500, the tailing factor should be less than 2.0. In the two mobile phase systems, the ratio of blue glucose 2000 peak retention time should be between 0.93 and 1.07, and the ratio of polymer peak to blue glucan 2000 peak in the corresponding chromatography solution should be between 0.93 and 1.07. Weighing amosilin in about 0.2g in a 10 ml bottle, plus 2% aqueous sodium carbonate solution 4 ml to dissolve, with 0.3mg/ml of blue glucose 2000 solution diluted to the scale, shake well. Take 100 to 200 μl injection liquid chromatography, with flow phase a for determination, record chromatography. The valley height ratio between the peak height of the high polymer and the monomer and the high polymer should be greater than 2.0. In addition, the flow phase b as the flow phase, precision quantity of control solution 100 to 200 μl, continuous sample 5 times, the relative standard deviation of peak area should not be greater than 5.0%.

2 control the preparation of the solution

Take penicillin control products in the appropriate amount, precision weighing, water dissolved and quantitatively diluted into each 1 ml containing about 0.2 mg of solution.

E-mail: lilyoo@bbcapharma.com

3 assay

Take this product about 0.2g, precision weighing, place 10 ml volume bottle, plus 2% aqueous sodium carbonate solution 4 ml soluble, diluted with water to scale, shake well, immediately precision amount of 100 to 200 μl injection chromatography, to flow phase a for the flow phase to determine, record chromatography. Another precision measuring control solution 100 to 200 μl injection chromatograph, with the flow phase b as the flow phase, the same method of determination. Based on the outer scale method, the peak area is calculated, and the result is divided by 10, i.E. It is obtained. Contains amoxicillin polymer in amoxicillin, not more than 0.15% (amoxicillin: penicillin : 1:10).

5 residual solvent

Acetone and dichloromethane precision claim this product 0.25g, empty bottle, precision plus dimethyl acetylamide 5 ml dissolved, sealed, as a test solution amount, plus dimethyl acetylamide quantitative dilution into each 1 ml containing about 40 mg of acetone and 30 μg of dichloromethane solution, precision amount of 5 ml, empty bottle, sealed, as a control solution. Measured by residual solvent determination (the second method of appendix viii.P, part ii of the 2010 edition of the pharmacopeia). Capillary columns with 6% cyanopropyl benzene-94% dimethyl polysiloxane (or similar polarity) as fixed liquid are columns of chromatography 6 min; inlet temperature is 300 degrees c, detector temperature is 250 degrees c; top-empty bottle balance temperature is 80 degrees c, balance time is 30 minutes; take control solution top-to-air sample, record chromatography, acetone and dichloromethane separation should meet the requirements. The sample solution and the control solution were taken from the top of the air and the chromatography was recorded. According to the external standard method to peak area calculation, the content of dichloromethane must not be more than 0.12%, containing acetone should comply with the provisions.

6 moisture

Take this product, according to the moisture determination method (2010 edition of the pharmacopeia ii appendix viii.M the first method a) determination, moisture content should be 12.0% to 15.0%.

7 burning residue

Take this product 1.0g, according to the law inspection (2010 edition of the pharmacopeia ii appendix viii.N), the residue must not be more than 1.0%.

Content Determination

Measured by the high-efficiency liquid chromatography method (appendix v. D of the 2010 edition of the pharmacopoeia ii).

1 chromatographic conditions and system suitability test

The silicone is filled with 18 alkyl silane bonding silicone, the potassium dihydrophosphate solution of 0.05mol/l (regulating ph to 5.0 with 2mol/l potassium hydroxide solution) - ethyl acetylene (97.5:2.5) is the flow phase, and the wavelength is detected at 254nm. Take about 25 mg of the applicability control of the arshilin system, place 50 ml volume bottle, dissolve with flow phase and dilute to scale, shake well, take 20 μl injection liquid chromatography, the recorded chromatography should be consistent with the standard map.

2 assay

Take this product about 25mg, precision weighing, place 50 ml volume bottle, plus flow phase dissolved and diluted to scale, shake well, precision quantity of 20 sl injection liquid chromatography, record chromatographic map; according to the external standard method in the peak area calculation, that is, get.

Category

β-lactam antibiotics, penicillin.

Storage

Blackout, sealed and saved.

Description of the Drug

Dosage Size

Tablets: 0.125g X 50, 0.25g X 50, 0.25g X 20. Capsules: 0.12g, 0.2g, 0.5g (c16h19n3o5s). Injection: 0.5g. Dry Syrup: 125mg, 250mg.

Pharmacological Effects

Amoxicillin is a semi-synthetic broad-spectrum penicillin drug, antibacterial spectrum and antibacterial activity is basically the same as ampicillin, but its acid resistance is stronger than ampicillin, its bactericidal effect is stronger and faster than the latter, but can not be used for the treatment of meningitis. The half-life is about 61.3 minutes. Amosilin is stable under acidic conditions, the gastrointestinal absorption rate is 90%, more rapid and complete than ampicillin absorption, except for the effect of shiga bacteria is worse than ampicillin, the rest of the effect is similar.

Amosilin has a strong bactericidal effect and a strong ability to penetrate cell walls. After oral drug molecules of the endamide base immediately hydrolyzed to produce peptide bonds, quickly and the bacteria in the body of transpeptide enzyme binding to make it inactivated, cut off the bacteria rely on transpeptide enzyme synthesis glycopeptide used to build cell walls the only way, so that bacterial cells quickly become spheres and ruptured dissolved, bacteria eventually due to cell wall loss, water penetration and bloating death. For most disease-causing g-bacteria and g-bacteria (including cocci and bacillus) have a strong antibacterial and bactericidal effect. Among them, streptococcus pneumoniae, hemolytic streptococcus and other streptococcus genus, non-production penicillin enzyme staphylococcus, fecal enterococci and other aerobic gram-positive bacteria, e. Coli, singular deformation bacteria, salmonella genus, haemophilus influenzae, gonorrhea neisseria and other oxycodone-negative bacteria do not produce β endaminomase strains and helicobacter pylori has good antibacterial activity. Hemodialysis can remove some drugs, but peritoneal dialysis has no effect on the removal of this product.

Sensitive bacteria: streptococcus a, b, c, f, g and non-group type, mononucleosis listeria, diphtheria, neisser meningitis bicecrotosis, pertussis bacteria, pygmylobacter genus, bacillus acetaus, digestive streptococcus, streptococcus, salmonella, fungal genus, line bacteria, hook-end helix, syphilis helix.

Instability sensitive bacteria: penicillin-sensitive or drug-resistant pneumococcal, enterobacteria, e. Coli, singular deformation bacteria, shigella, vibrio cholerae, haemophilus influenzae, gonorrhea neisseria, clostridium difficile.

Drug-resistant bacteria: staphylococcus aureus, carta genus, acid-producing cree white bacteria, pneumococcal bacteria, common deformed bacteria, pseudo-monosporidium genus, immobilized bacteria, campylobacter, verongococcal bacteria, mycoplasm, rikersian, legionella genus, bacillus bacteria, fragile bacteria.

Toxicology: not clear yet

E-mail: lilyoo@bbcapharma.com

Indications

Amosilin can be used to treat typhoid fever, other salmonella infections and typhoid carriers with satisfactory efficacy. Treatment of sensitive bacteria do not produce β the strain of endamide enzyme caused by urinary tract infection also obtained good results, for patients with lower urinary tract infection and non-production enzyme gonorrhea nesser bacteria urethritis, cervicitis, oral single dose of 3g can obtain satisfactory efficacy. Streptococcus pneumoniae, penicillin-inoculated luminoporia, hemolytic streptococcus and haemophilus influenzae, which does not produce β endaminase, are all indications. Amoxilin is also available for leptospirosis. This product can also be used for urological system infections caused by sensitive e. Coli, singular deformation bacteria and fecal enterococci. This product has good efficacy in treating helicobacter pylori infection in combination with kramycin and lansolazole.

Amoxicillin is suitable for the following infections caused by sensitive bacteria (no β-endamide enzyme strains):

(1)Upper respiratory tract infections such as hemoglobin, streptococcus pneumoniae, staphylococcus or haemophilus influenzae, otitis sinusitis, pharyngitis, tonsillitis, etc.;

(2) Urological tract infections caused by e. Coli, singular deformation bacillus or fecal enterococci;

(3) Skin soft tissue infection caused by streptococcus, staphylococcus or e. Coli;

(4) Acute bronchitis, pneumonia and other lower respiratory tract infections caused by streptococcus hemophilus, streptococcus pneumoniae, staphylococcus aureus or haemophilus influenzae;

(5) Acute simple gonorrhea;

(6) Can be used to treat typhoid fever, other salmonella infections, typhoid carriers and leptospirosis, amoxicillin can also be used with kramycin, lansolazoine triad drugs to eradicate the stomach, duodenal helicobacter pylori, reduce the recurrence rate of digestive ulcers.

Adverse Reactions

The incidence of adverse reactions in clinical applications of ammoxilin was about 5 to 6%, and about 2% of those who stopped the drug due to the reaction. The main adverse reactions are:

1. Allergic reaction symptoms: drug fever, urticaria, rash and asthma, especially in infectious mononucleosis patients, rare allergic shock.

2. Digestive system symptoms: more symptoms such as diarrhea, nausea, vomiting, occasionally false membrane colitis and other gastrointestinal reactions.

3. Symptoms of the blood system: occasional increase in eosinophils, white blood cell reduction, platelet reduction, anemia, etc.

4. Skin mucous membrane reaction: occasionally see plaque papules, oozing polymorphic erythema, lyell syndrome, peeling dermatitis.

5. Liver and kidney dysfunction: a small number of patients after medication occasionally see a mild increase in serum amino transferase, acute interstitial nephritis.

6. Other: central nervous system symptoms such as excitement, anxiety, insomnia, dizziness, and behavioral abnormalities. Long-term use of this medicine can occur by candida or drug-resistant bacteria caused by the dual infection.

7. Convulsions and eosinophils can be seen when intravenous injections are high.

Taboo

The state health department requires penicillin skin tests before use, which are banned by those who are positive. In addition, penicillin sodium, potassium penicillin, etc. Are also penicillin antibiotics, before use must do skin test. Inconvenient to do skin testing can first take a third of a pill, an hour later if there are no adverse reactions can be taken normally, if you feel unwell as soon as possible to the hospital.

1. People who are allergic to one penicillin may be allergic to other penicillin, or may be allergic to penicillin or cephalosporins, and must have a penicillin skin test before taking the drug, which is disabled by the positive person.

2. Infectious mononucleosis, lymphocytic leukemia, cytometic viral infection, lymphoma and other patients disabled.

3. People with a history of allergic diseases such as asthma, eczema, hay fever, urticaria, etc.;

4. The determination of urinary sugar with a flaky reagent (r) containing copper sulfate may lead to false positive reactions, and elevated serum transaminase, increased eosinophils and decreased white blood cells can occur after a few patients have taken the drug.

5. Pregnant and lactating women and children under 3 months of age should be used with caution. After application in late pregnancy, the concentration of estrogen in plasma can be reduced, but has no effect on free estrogen and progesterone. This product can be discharged by breast milk, breast milk after the use of this product can make the baby allergenic.

Amocillin has a variety of dosage forms, including injections, capsules, tablets, punches, etc., But no matter what dosage form, the storage environment requirements are very high, should be shaded, sealed, in a cool and dry place to save. Even if the storage conditions are suitable, amossylin may still occur during the placement process, such as decomposition and polymerization of chemical changes, the formation of new allergic substances. In hot and humid seasons, the rate of failure of this deterioration will also accelerate. In addition, amoxicillin and aminosaccharides (e.G. Qingdamycin, carnamycin), cycloprophenid, pefluosa star and other drugs, belong to the taboo, can not be placed in the same container. The use of amosylin capsules must be followed by a doctor's order, as a family-prepared medicine to take their own both blind and dangerous. In the course of taking amosaicillin, if there is an allergic reaction such as a rash, or severe digestive system adverse reactions, such as diarrhea, vomiting, etc., Must be stopped immediately.

Drug Interactions

1. Propulsion can delay the excretion of amoxicillin through the kidneys (competitively reduce the secretion of amoxicillin's renal tubes), prolong its serum half-life, thus increasing the concentration of blood drugs in this product.

2. When ammoxilin is used in combination with amino glycosides, the in vitro sterilization effect of amocylin on fecal streptococcus can be enhanced at the concentration of sub-suppressive bacteria.

3. When amoxicillin is combined with β-intraamide enzyme inhibitors such as kravic acid, the antibacterial effect is significantly enhanced. Kravic acid not only enhances the sensitivity of β-lactam enzyme strains to amoxicillin to varying degrees, but also enhances the role of amoxicillin in certain non-sensitive strains, including mycobacterium, legionella, noka and pseudo-nose anthrax.

4. Chloramphenicol, large cycloestes, amines and tetracycline in vitro can interfere with the antibacterial effects of this product, but its clinical significance is unknown.

5. When amoxilin is used in combination with the pill, it can interfere with the intestinal liver circulation of the pill, thereby reducing its efficacy.

6. The inhibitors of uric acid synthesis can increase the risk of adverse skin reactions in amoxicillin.

7. When amoxicillin is used in combination with methotrexate, this product can reduce the renal clearance rate of methotrexate, thus increasing the toxicity of methotrexate.

8. Food can delay the absorption of amoxilin, but food does not significantly reduce the total amount of drug absorption.

E-mail: lilyoo@bbcapharma.com

Pharmacokinary Dynamics

Oral absorption of this product quickly, about 75% to 90% can be absorbed from the gastrointestinal tract, food on drug absorption effect is not significant. Oral 0.25g and 0.5g post-blood peak concentration (cmax) were 3.5 to 5.0mg/l and 5.5 to 7.5mg/l, respectively, with peak time of 1 to 2 hours. This product is well distributed in most tissues and body fluids. The average drug concentrations in sputum for 2 to 3 hours and 6 hours after oral 0.5g of this product were 0.52 mg/l and 0.53 mg/l, respectively, compared with 11 mg/l and 3.5 mg/l in the same period. Children with chronic otitis media oral product 1 g after 1 to 2 hours, the concentration of drugs in the middle ear liquid is 6.2 mg/l. The concentration in cerebrospinal fluid was 0.1g to 1.5mg/l in 2 hours after oral intake of this product, equivalent to 0.9% to 21.1% of the concentration of blood drugs in the same period. This product can be through the placenta, the concentration in the cord blood is 1/4 to 1/3 of the concentration of maternal blood drugs, in the milk, sweat and tears also contain trace amounts. The protein binding rate of amosaicin was 17% to 20%. The half-life of blood removal (t1/2 beta) is 1 to 1.3 hours, after taking about 24% to 33% of the dose in the liver metabolism, within 6 hours 45% to 68% of the dose of the original drug from urine excluded, there are still some drugs excreted through the bile duct, severe renal insufficiency patients serum half-life can be extended to 7 hours. Hemodialysis can remove this product. Peritoneal dialysis has no effect on the removal of this product.

Instructions for Administration

1. In order to prevent the occurrence of severe allergic reactions, amoxicillin must ask in detail about past medical history, including the history of drug use, whether penicillin drugs have been used, whether there are reaction symptoms that are easily overlooked by patients, such as chest tightness, itching, facial hemp, fever, etc., And whether there are any personal or family abnormal reaction diseases.

2. Penicillin g-skin test shall be administered when injecting or intravenously in amoxicillin, and those who test positive for the skin should not use this medicine.

3. In the case of medication, once an allergic reaction occurs, it must be rescued in place. Immediately give the patient 0.1% adrenaline 0.5 to 1ml, if necessary, 5% glucose injection or sodium chloride injection diluted for intravenous injection. Clinical performance is not improved, repeated after half an hour, heart stoppers, can be injected with adrenaline heart, while intravenously dripped high doses of epinephrine corticosteroids, and supplement blood volume. People with persistent blood pressure may be given vascular active drugs such as dopamine. Antihistamines may also be considered to reduce urticaria. People with breathing difficulties should be oxygen inhalation or artificial respiration, throat edema is obvious, should be timely trachea incisive.

4. Amosilin oral preparations are only used for mild to moderate infections. Take after meals to reduce gastrointestinal reactions.

5. Amoxicillin is easy to hydrolysis, β-endamide cyclos in aqueous solution is easy to crack, hydrolysis rate accelerates with temperature, so injection should be freshly formulated, not suitable for preparation after long-term.

6. Amoxicillin and aminosaccharides (e.G. Gydamycin, carnamycin), cycloprophenid, pefluosa star and other drugs are taboo, when used in the same container.

7. Medication must be discontinued during or after treatment for severe persistent diarrhea (possibly pseudofilm colitis).

8. Treatment of drug overdoses: supportive treatment and treatment of symptoms may be taken in the event of an overdose.

9. Since its absorption in the gastrointestinal tract is not affected by food, it can be taken on an empty stomach or after meals and can be taken with foods such as milk.

10. Infectious mononucleosis patients should not use this medicine.

Usage Usage

1. Oral: (1) adults 1 time 0.5g, every 6 to 8 hours 1 time, daily dose not more than 4g; treatment of uncomplicated acute urinary tract infection can be a single oral product 3g, can also be added after 10 to 12 hours 3g dose. A single 3g dose can also be used to prevent infectious endocarditis or treat simple gonorrhea, which is given 1 hour before intra-oral surgery (e.G. Tooth extraction), and propylene sulfonation 1g. (3) newborns and premature babies are given 50 mg orally once, once in 12 hours; (4) the half-life of this product in patients with advanced renal failure can be extended from the normal 0.9 to 2.3 hours to 5 to 20 hours, so in patients with 10 to 50 ml/min and less than 10 ml/min, the inter-administration period should be 8 to 12 hours and 16 hours, respectively. Hemodialysis can affect the concentration of blood drugs, after each hemodialysis should be 1g amoxilin. 2. Intramuscular injection or dilution of intravenous drip, 1 time 0.5 to 1g, 3 to 4 times per day;

Oral: adults and children weighing more than 40 kg each time 1 to 2 capsules (0.25 to 0.5 g), every 6 to 8 hours, a daily dose of no more than 4g (16 capsules); take 2 to 3 times; infants under 3 months of age 30 mg/kg/day, take in 1 12 hours; patients with severe renal impairment need to adjust the dose of administration, wherein endogenous creatinine removal rate is 10 to 30 ml / patients every 12 hours 0.25 to 0.5g. This product can be taken on an empty stomach or after meals, and can be taken with food such as milk. Nasser's gonorrhea urethritis can be taken orally 3g alone;

Intramuscular injections: 0.5 to 1g/time, 3 to 4 times a day.

Intravenous drip: 0.5 to 1g/time, 3 to 4 times a day.

Those with severe renal deficiency should extend the interval between medications, those with a gloer filtration rate of 10 to 15 ml/min, and administer the drug once in 8 to 12 hours, and once in 12 to 16 hours for those with less than 10 ml/min.

E-mail: lilyoo@bbcapharma.com

Medication for Pregnant and Lactating Women

Animal reproductive tests showed that amosylin, which is 10 times the human dose, did not impair the fertility and fetuses of rats and mice. However, there is not enough controlled studies in humans, and given that animal reproductive tests do not fully predict human response, pregnant women should apply this product only when necessary. Since a small amount of ammoxilin can be secreted in the milk, it can cause allergies in infants after taking it.

Children's Medicine

It is not clear.

The old man took medicine

It is not clear.

Poisoning

Amoxicillin (hydroxyamphenicol) is Used to Treat Typhoid Fever, Other Salmonella Infections and Typhoid Carriers, Urinary Tract Infections Caused by Sensitive Bacteria, As Well As Pneumococcal Bacteria, Staphylococcus Aureus, Hemolytic Streptococcus, and Leptospirosis of Influenza Infections. Oral Absorption, the Protein Binding Rate of This Product 17% to 20%, Half-life of 1 to 1.3h, Late Kidney Failure, Half-life Can Be Extended to 5 to 20h. Common Amount 0.5 to 1.0g, 3/d, Oral.

Clinical Manifestations

1. Common adverse reactions are diarrhea, nausea, vomiting and other digestive tract symptoms are more common, about 3.1%.

2. The incidence of rash is about 2%, there are still drug fever, asthma, individual serum transaminase elevation, occasionally erythropoietic cell hyperplative and granulocyte reduction occurred.

Treat

The main treatment points for ammosillin poisoning are:

1. See penicillin for information.

2. Hemodialysis can clear the blood of the product, peritoneal dialysis is not effective

Drug Overdose

A prospective study involving 51 child patients suggested that amosylin did not cause significant clinical symptoms when administered at doses of up to 250 mg/kg. A small number of patients have been reported to have renal insanity and less urine due to amosylin overdoses, but renal damage is reversible after discontinuation.

Gastric Disease Treatment

Potassium nitrite 110mg, 4 times a day, 30 minutes before meals and oral before bedtime; omerazole 10mg, once a day, four weeks for a course of treatment can be very good to relieve symptoms of stomach disease, treatment of stomach disease, but also to repair the stomach mucosa and damage to the stomach, reduce the side effects of western medicine.

E-mail: lilyoo@bbcapharma.com
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