Ciprofloxacin Tablets

Ciprofloxacin Tablets used for sensitive bacteria caused

(1) urological system infections, including simple, complex urinary tract infections, bacterial prostatitis, gonorrhea neisseria urinary tractitis or cervicitis (including those caused by enzyme strains).

(2) respiratory infections, including acute episodes of bronchial infections caused by sensitive gram-negative bacteria and lung infections.

(3) gastrointestinal infections, caused by shiga, salmonella, enterotoxin-producing e. Coli, hydrophilic monocytobacteria, parahydromobacteria, etc.

(4) typhoid fever.

(5) bone and joint infections.

(6) skin soft tissue infection.

(7) sepsis and other systemic infections.

Ingredient

The main ingredients of this product are: hydrochloric acid ring propylene sand star. Its chemical name is: 1-cyclopropyl-6-fluorine-1, 4-dihydro-4-oxygen-7-(1-pyridine-3-hydrochloric acid hydrate.

Structure:

Molecular: C₁₇H₁₈FN₃O₃· HCl· H₂O

Molecular weight: 385.82

E-mail: lilyoo@bbcapharma.com

Characters

This product is a thin film coating, remove the coat after the appearance of white to slightly yellow.

Indications

Used For Sensitive Bacteria:

(1) urological system infections, including simple, complex urinary tract infections, bacterial prostatitis, gonorrhea neisseria urinary tractitis or cervicitis (including those caused by enzyme strains).

(2) respiratory infections, including acute episodes of bronchial infections caused by sensitive gram-negative bacteria and lung infections.

(3) gastrointestinal infections, caused by shiga, salmonella, enterotoxin-producing e. Coli, hydrophilic monocytobacteria, parahydromobacteria, etc.

(4) typhoid fever.

(5) bone and joint infections.

(6) skin soft tissue infection.

(7) sepsis and other systemic infections.

Specification

0.25g / 0.5g / 0.75g by csophartune

Usage Usage

Take Orally.

(1) Common Adults: 0.5 To 1.5g (2 To 6 Tablets) A Day, Divided Into 2 To 3 Times.

(2) Bone And Joint Infections: 1 To 1.5g (4 To 6 Tablets) A Day, 2 To 3 Times, 4 To 6 Weeks Or More.

(3) Pneumonia And Skin Soft Tissue Infection: 1 To 1.5g (4 To 6 Tablets) A Day, Divided Into 2 To 3 Times, The Course Of Treatment 7 To 14 Days.

(4) Intestinal Infection: 1g (4 Tablets) A Day, Divided Into 2 Sessions, Course 5 To 7 Days.

(5) Typhoid Fever: 1.5g (6 Tablets) A Day, 2 To 3 Times, 10 To 14 Days.

(6) Urinary Tract Infection: Acute Simple Urinary Tract Infection, 0.5g (2 Tablets) A Day, Divided Into 2 Sessions, Course 5 To 7 Days; Complex Urinary Tract Infection, 1g (4 Tablets) A Day, Divided Into 2 Sessions, Treatment 7 To 14 Days.

(7) Simple Gonorrhea: 0.5g (2 Tablets) Per Oral Session.

E-mail: lilyoo@bbcapharma.com

Adverse Reactions

(1) gastrointestinal reactions are more common and can manifest themses as abdominal discomfort or pain, diarrhea, nausea or vomiting.

(2) central nervous system reactions can include dizziness, headache, drowsiness or insomnia.

(3) allergic reactions: rash, itching of the skin, occasionally oozing polymorphic erythema and vascular neuroedema. A small number of patients have photosensitive reactions.

(4) occasional occurrence:

a)        seizures, mental abnormalities, irritability, confusion,hallucinations, tremors;

b)        the manifestations of interstitial nephritis such as hematuria, fever, rash, etc.;

c)        crystallized urine, most commonly found in high-dose applications;

d)        joint pain.

(5) a small number of patients can occur serum transaminase and hematuroan nitrogen increase and the surrounding blood elephant white blood cells decreased, mostly mild, and showed a pass.

Taboo

Banned in patients who are allergic to this product and quinolones.

Precautions

(1) due to the current e. Coli resistance to fluoroquinolones, urine culture specimens should be left before administration, with reference to bacterial drug sensitivity results to adjust medication.

(2) this product should be taken on an empty stomach, although the food can delay its absorption, but its total absorption (bioavailability) has not decreased, it can also be taken after meals to reduce gastrointestinal reactions;

(3) crystallized urine can occur when the high dose application or urine ph of this product is above 7. In order to avoid the occurrence of crystalline urine, it is advisable to drink more water, to maintain 24-hour urination in more than 1200 ml.

(4) renal function is reduced, according to the kidney function to adjust the dose of administration.

(5) the application of fluoroquinolones can occur in the occurrence of moderate and severe photosensitive reactions. Use this product to avoid excessive exposure to sunlight, such as photosensitivity reactions need to stop medicine.

(6) liver function decline, such as severe (liver cirrhosis ascites) can reduce drug removal, blood concentration increased, liver and kidney function are particularly obvious, all need to weigh the pros and cons of application, and adjust the dose.

(7) patients with the original central nervous system disease, such as epilepsy and epilepsy history should avoid the application, there are indications need to carefully weigh the pros and cons after the application.

E-mail: lilyoo@bbcapharma.com

Medication for Pregnant and Lactating Women

Animal experiments have not confirmed the teratogenic effect of quinolones, but there is no clear conclusion in the study of drug use in pregnant women. In view of the fact that this medicine can cause joint lesions in juvenile animals, pregnant women are prohibited, and breastfeeding women should suspend breastfeeding when applying this product.

Children's Medicine

The safety of this product for infants and young people under 18 years of age has not yet been determined. However, when used in several species of juvenile animals, it can cause joint lesions. Therefore, it should not be used for children and adolescents under 18 years of age.

Medication for the Elderly

Elderly patients often have renal function decline, because the part of this product is excreted by the kidney, need to reduce the application.

Drug Interactions

(1) urinary alkalinization drugs can reduce the solubility of this product in the urine, resulting in crystalline urine and renal toxicity.

(2) acid-making drugs containing aluminum or magnesium can reduce the oral absorption of this product, it is recommended to avoid joint use. When not avoidable, take this product 2 hours before or 6 hours after taking the medicine.

(3) this product may be used in combination with the tea-alkali class due to cytchrome p450competitive inhibition of the binding site led to a significant reduction in the liver elimination of the caernamine group and a reduction in blood elimination half-life (t).1/2βprolonged, increased concentration of blood drugs, the appearance of symptoms of tea-alkali poisoning, such as nausea, vomiting, tremor, restlessness, agitation, convulsions, palpitations, etc., So the combined use should determine the concentration of the hemp-alkali blood drugs and adjust the dose.

(4) when cyclosporine is used in combination with this product, the concentration of blood drugs increases, and the blood concentration of cyclosporine must be monitored and the dose adjusted.

(5) this product and anticoagulant warfarin can enhance the anticoagulant effect of the latter, when combined with the patient's clotting enzyme original time should be closely monitored.

(6) propulsion can reduce the secretion of this product from the renal tube about 50%, when combined with this product blood concentration can be increased toxicity.

(7) this product interferes with the metabolism of caffeine, resulting in reduced caffeine elimination and blood elimination half-life (t).1/2βprolonged and may produce central nervous system toxicity.

(8) dehydroxyosine (ddi) can reduce the oral absorption of this product, because its preparation contains aluminum and magnesium, can be chelated with this product, it is not suitable for use.

E-mail: lilyoo@bbcapharma.com

Drug Overdose

It is not clear.

Pharmacological Toxicology

This product has a broad-spectrum antibacterial effect, especially on aerobic gram-negative bacteria antibacterial activity is high, the following bacteria in vitro have a good antibacterial effect: e. Coli most bacteria, including e. Coli genus, culvert, e. Coli, e. Coli, e. Coli, creberia genus, deformation bacillus genus, salmonella genus, shigella genus, vibrio bacteria genus, jermyll bacteria and so on. Often on multi-drug-resistant bacteria also have antibacterial activity. The genus neseria, haemophilus influenzae and mora bacteria, which are resistant to penicillin, are highly antibacterial. Most strains of pseudomonas such as copper-green pseudomonas have antibacterial effects. This product has antibacterial activity on methicillin-sensitive staphylococcus, and only moderate antibacterial activity on streptococcus pneumoniae, hemolytic streptococcus and fecal enterococci. It has good antimicrobial effect on tracha trachalin, mycoplasma and legionella, and also has antibacterial activity on tb and atypical mycobacterium. Poor antibacterial activity against anaerobic bacteria.

Cyclopaedia is a fungicide that inhibits the synthesis and replication of dna by acting on a subunits of bacterial dna helix enzymes.

Pharmacokinary Dynamics

Healthy population after taking this product 0.2g or 0.5g, its blood peak concentration (cmax) is 1.21 μg/ml and 2.5μg/ml, respectively, peak time (t).Max1 to 2 hours. Widely distributed to the tissues, body fluids (including cerebrospinal fluid), the concentration in the tissue often exceeds the concentration of blood drugs, protein binding rate of about 20% to 40%. Blood elimination half-life (t1/2β4 hours. It can be metabolized in parts of the liver, and metabolites are still weakly active. Oral administration 24 hours after the original kidney discharge of 40% to 50% of the amount of the drug. About 15% are excreted in the form of metabolites. At the same time, some of the drugs are excreted by bile and feces.

Storage

Blackout, Sealed and Saved.

Wrap

Aluminum plastic packaging, 6 pieces per plate, each small box contains 1 plate.

Aluminum plastic packaging, 6 pieces per plate, each small box contains 2 plates.

Aluminum plastic packaging, 6 pieces per plate, each small box contains 4 plates.

Expiration Date

36 months.

Enforce The Standard

The 2010 edition of the chinese pharmacopoeia.

Pregnancy Rating

Fda pregnancy rating: C

Lactation Grading

Cyclostar hydrochloride: cycloprosate l3, half-life 4.1h if used by nursing mothers, the baby's gastrointestinal symptoms, such as diarrhea, should be closely monitored. Recent studies have shown very low levels of breast milk. There are several types of eye medications in this product, which can be used because the absolute dose used is very small.